For moist lesions, a small quantity of the cream should be rubbed gently into the affected areas 2 or 3 times a day.  
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Methadone may be expected to have additive effects when used in conjunction with alcohol, other opioids or CNS depressants, or with illicit drugs that cause central nervous system depression.  
Treatment of acute overdosage is by supportive and symptomatic therapy.  
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The signs and symptoms of NMH are similar to those of orthostatic hypotension.  
Treatment with intravenous ibutilide fumarate for acute termination of recent onset atrial flutter/fibrillation was evaluated in 466 patients participating in two randomized, double-blind, placebo-controlled clinical trials.