Following oral administration, when postural hypotension has occurred, it has been transient and is uncommon when the recommended starting dose and titration increments are closely followed (see [#section-10 DOSAGE AND ADMINISTRATION]). Symptomatic postural hypotension is most likely to occur 2 to 4 hours after a dose, especially following the use of large initial doses or upon large changes in dose.  
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Approximately the same amount of desglymidodrine is formed after intravenous and oral administration of midodrine.  
It's less likely that women will notice these symptoms during physical activity (such as jogging or walking fast).  
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Some patients choose to manage TN using complementary techniques, usually in combination with drug treatment.  
Drugs that interfere with hemostasis (e.g., NSAIDs, Aspirin, Warfarin) вЂ” Serotonin release by platelets plays an important role in hemostasis.