Such patients should be allowed to develop a tolerance through the initial administration of a small dose and gradual increase in dose until an effective level is reached.  
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In mice, a single intravenous dose of rapidly administered ETOPOPHOS was lethal at or above 120 mg/kg (about 7 times human dose on a mg/m2 basis) and was associated with clinical signs of neurotoxicity.  
Retinal detachment is the main cause of visual impairment and blindness in ROP.  
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Oral contraceptive pills (OCPs, birth control pills) are used in some women with PCOS to establish a regular menstrual cycle and to reduce the risk of endometrial hyperplasia and cancer by establishing regular menstrual periods.  
If angioplasty fails or is not technically feasible, formal bypass surgery may be considered.